Stem Cells International / 2014 / Article / Tab 2

Research Article

Reducing TRPC1 Expression through Liposome-Mediated siRNA Delivery Markedly Attenuates Hypoxia-Induced Pulmonary Arterial Hypertension in a Murine Model

Table 2

Baseline characteristics of three group animals at day 28 after hypoxia-induced pulmonary arterial hypertension.

Variable Group 1 ( = 10)Group 2 ( = 10)Group 3 ( = 10)-value*

Body weight (g)24.91 ± 1.3925.04 ± 2.3225.08 ± 1.360.977
RBC count (1.0 × 106/mL)8.14 ± 0.33a10.10 ± 1.05b10.12 ± 1.52b<0.001
Hemoglobulin (gm/dL) 11.83 ± 0.45a14.73 ± 1.52b14.61 ± 2.27b<0.001
RVSP (mm Hg)20.89 ± 1.69a39.31 ± 3.37b29.57 ± 1.77c<0.001
LVSP (mm Hg) 103.38 ± 10.4894.96 ± 15.1194.97 ± 15.070.410
RV weight (g)0.021 ± 0.012a0.028 ± 0.003b0.023 ± 0.025a<0.001
Total HW (g)0.107 ± 0.4040.127 ± 0.0150.119 ± 0.1250.119
Ratio of RV/total HW 0.178 ± 0.015a0.222 ± 0.302b0.189 ± 0.018a<0.001
Total lung weight (g)0.145 ± 0.009a0.193 ± 0.027b0.160 ± 0.028a<0.001

Data are expressed as means ± SD.
RBC = red blood cell; RVSP = right ventricular systolic pressure; LVSBP = left ventricular systolic blood pressure; HW = heart weight.
Group 1 = sham control; group 2 = hypoxia + negative control siRNA; group 3 = hypoxia + siRNA-TRPC1.
*By one-way ANOVA.
Different letters (a, b, c) are being used for grouping, showing significant difference (at level 0.05) among different groups by Tukey’s multiple comparison procedure.

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