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Stem Cells International
Volume 2014, Article ID 516278, 9 pages
http://dx.doi.org/10.1155/2014/516278
Review Article

Stem Cells: Innovations in Clinical Applications

1Department of Pediatrics, Case Western Reserve University, Cleveland, OH 44106-4948, USA
2Hathaway Brown School, 19600 North Park Boulevard, Shaker Heights, OH 44122, USA

Received 23 August 2013; Revised 8 December 2013; Accepted 13 January 2014; Published 7 July 2014

Academic Editor: Rita Anzalone

Copyright © 2014 Morgan T. Sutton and Tracey L. Bonfield. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. T. L. Bonfield, “Cell based therapy aides in infection and inflammation in the murine model of Cystic Fibrosis and lung disease,” Stem Cell Discovery, vol. 3, no. 2, pp. 139–153, 2013. View at Google Scholar
  2. T. L. Bonfield, M. T. Nolan, D. P. Lennon, and A. I. Caplan, “Defining human mesenchymal stem cell efficacy in vivo,” Journal of Inflammation, vol. 7, article 51, 2010. View at Publisher · View at Google Scholar · View at Scopus
  3. A. I. Caplan and D. Correa, “The MSC: an injury drugstore,” Cell Stem Cell, vol. 9, no. 1, pp. 11–15, 2011. View at Publisher · View at Google Scholar · View at Scopus
  4. J. M. Sorrell, M. A. Baber, and A. I. Caplan, “Influence of adult mesenchymal stem cells on in vitro vascular formation,” Tissue Engineering A, vol. 15, no. 7, pp. 1751–1761, 2009. View at Google Scholar
  5. L. da Silva Meirelles, A. M. Fontes, D. T. Covas, and A. I. Caplan, “Mechanisms involved in the therapeutic properties of mesenchymal stem cells,” Cytokine and Growth Factor Reviews, vol. 20, no. 5-6, pp. 419–427, 2009. View at Publisher · View at Google Scholar · View at Scopus
  6. G. Ren, L. Zhang, X. Zhao et al., “Mesenchymal stem cell-mediated immunosuppression occurs via concerted action of chemokines and nitric oxide,” Cell Stem Cell, vol. 2, no. 2, pp. 141–150, 2008. View at Publisher · View at Google Scholar · View at Scopus
  7. M. B. Murphy, “Mesenchymal stem cells: environmentally responsive therapeutics for regenerative medicine,” Experimental and Molecular Medicine, vol. 45, article e54, 2013. View at Google Scholar
  8. J. M. Sorrell, M. A. Baber, and A. I. Caplan, “Influence of adult mesenchymal stem cells on in vitro vascular formation,” Tissue Engineering A, vol. 15, no. 7, pp. 1751–1761, 2009. View at Publisher · View at Google Scholar
  9. A. Stoff, S. T. Moore, T. M. Numnum et al., “Promotion of incisional wound repair by human mesenchymal stem cell transplantation,” Experimental Dermatology, vol. 18, no. 4, pp. 362–369, 2009. View at Publisher · View at Google Scholar · View at Scopus
  10. V. Falanga, S. Iwamoto, M. Chartier et al., “Autologous bone marrow-derived cultured mesenchymal stem cells delivered in a fibrin spray accelerate healing in murine and human cutaneous wounds,” Tissue Engineering, vol. 13, no. 6, pp. 1299–1312, 2007. View at Publisher · View at Google Scholar · View at Scopus
  11. S. Ghannam, C. Bouffi, F. Djouad, C. Jorgensen, and D. Noël, “Immunosuppression by mesenchymal stem cells: mechanisms and clinical applications,” Stem Cell Research and Therapy, vol. 1, no. 1, article 2, 2010. View at Publisher · View at Google Scholar · View at Scopus
  12. T. M. Dexter, T. D. Allen, and L. G. Lajtha, “Conditions controlling the proliferation of haemopoietic stem cells in vitro,” Journal of Cellular Physiology, vol. 91, no. 3, pp. 335–344, 1977. View at Google Scholar · View at Scopus
  13. C. Shi, “Recent progress toward understanding the physiological function of bone marrow mesenchymal stem cells,” Immunology, vol. 136, no. 2, pp. 133–138, 2012. View at Publisher · View at Google Scholar · View at Scopus
  14. A. Shafiee, M. Soleimani, G. A. Chamheidari et al., “Electrospun nanofiber-based regeneration of cartilage enhanced by mesenchymal stem cells,” Journal of Biomedical Materials Research A, vol. 99, no. 3, pp. 467–478, 2011. View at Publisher · View at Google Scholar · View at Scopus
  15. R. Scott and C. F. Hyer, “Role of cellular allograft containing mesenchymal stem cells in high risks foot and ankle reconstruction,” Foot and Ankle Surgery, vol. 52, no. 1, pp. 32–35, 2013. View at Publisher · View at Google Scholar
  16. A. Schmitt, M. van Griensven, A. B. Imhoff, and S. Buchmann, “Application of stem cells in orthopedics,” Stem Cells International, vol. 2012, Article ID 394962, 11 pages, 2012. View at Publisher · View at Google Scholar · View at Scopus
  17. F. Granero-Molto, J. A. Weis, M. I. Miga et al., “Regenerative effects of transplanted mesenchymal stem cells in fracture healing,” Stem Cells, vol. 27, no. 8, pp. 1887–1898, 2009. View at Publisher · View at Google Scholar · View at Scopus
  18. P. Lin, A. Caplan, T. J. Kean et al., “Serial transplantation and long-term engraftment of intra-arterially delivered clonally derived mesenchymal stem cells to injured bone marrow,” Molecular Therapy, vol. 22, no. 1, pp. 160–168, 2014. View at Google Scholar
  19. A. Giordano, U. Galderisi, and I. R. Marino, “From the laboratory bench to the patient's bedside: an update on clinical trials with Mesenchymal Stem Cells,” Journal of Cellular Physiology, vol. 211, no. 1, pp. 27–35, 2007. View at Publisher · View at Google Scholar · View at Scopus
  20. H. M. Lazarus, S. E. Haynesworth, S. L. Gerson, N. S. Rosenthal, and A. I. Caplan, “Ex vivo expansion and subsequent infusion of human bone marrow-derived stromal progenitor cells (mesenchymal progenitor cells): implications for therapeutic use,” Bone Marrow Transplantation, vol. 16, no. 4, pp. 557–564, 1995. View at Google Scholar · View at Scopus
  21. M. F. Pittenger, A. M. Mackay, S. C. Beck et al., “Multilineage potential of adult human mesenchymal stem cells,” Science, vol. 284, no. 5411, pp. 143–147, 1999. View at Publisher · View at Google Scholar · View at Scopus
  22. A. Fabbio, M. Prato, and L. Ballerini, “Carbon nanotubes in neuroregeneration and repair,” Advanced Drug Delivery Reviews, vol. 65, no. 15, pp. 2034–2044, 2013. View at Publisher · View at Google Scholar
  23. T. I. Chao, S. Xiang, C. S. Chen et al., “Carbon nanotubes promote neuron differentiation from human embryonic stem cells,” Biochemical and Biophysical Research Communications, vol. 384, no. 4, pp. 426–430, 2009. View at Publisher · View at Google Scholar
  24. Danielyan, “Inhaling stem cells for treating Parkinson's,” Cell Medicine. In press.
  25. O. N. Koc, J. Day, M. Nieder, S. L. Gerson, H. M. Lazarus, and W. Krivit, “Allogeneic mesenchymal stem cell infusion for treatment of metachromatic leukodystrophy (MLD) and Hurler syndrome (MPS-IH),” Bone Marrow Transplant, vol. 30, no. 4, pp. 215–222, 2002. View at Google Scholar
  26. T. L. Bonfield and A. I. Caplan, “Adult mesenchymal stem cells: an innovative therapeutic for lung diseases,” Discovery Medicine, vol. 4, no. 47, pp. 337–345, 2010. View at Google Scholar
  27. Y. Zhao, “New hope for diabetics: adult blood stem cells can make insulin,” Discovery Medicine, vol. 7, no. 38, pp. 63–67, 2007. View at Google Scholar · View at Scopus
  28. J. C. Voltarelli, C. E. Couri, M. C. Rodrigues et al., “Stem cell therapies for type 1 diabetes mellitus,” Indian Journal of Experimental Biology, vol. 49, no. 6, pp. 395–400, 2011. View at Google Scholar
  29. S. Sukpat and S. Patumraj, “Vasculoprotective effects of combined endothelial progenitor cells and mesenchymal stem cells in diabetic wound care: their potential role in decreasing wound-oxidative stress,” BioMed Research International, vol. 2013, Article ID 459196, 8 pages, 2013. View at Publisher · View at Google Scholar
  30. A. R. Brody, N. D. Salazar, and S. M. Lankford, “Mesenchymal stem cells modulate lung injury,” Proceedings of the American Thoracic Society, vol. 7, no. 2, pp. 130–133, 2010. View at Publisher · View at Google Scholar
  31. A. Tzouvelekis, A. Antoniadis, and D. Bourus, “Stem cell therapy in pulmonary fibrosis,” Current Opinion in Pulmonary Medicine, vol. 17, no. 5, pp. 368–373, 2011. View at Publisher · View at Google Scholar
  32. R. N. Toonkel, J. M. Hare, M. A. Matthay, and M. K. Glassberg, “Mesenchymal stem cells and idiopathic pulmonary fibrosis. Potential for clinical testing,” The American Journal of Respiratory and Critical Care Medicine, vol. 188, no. 2, pp. 133–140, 2013. View at Publisher · View at Google Scholar
  33. I. P. Nueringer and S. H. Randell, “Lung stem cell update: promise and controversy,” Mondali Arch Chest Discovery, vol. 65, pp. 47–51, 2006. View at Google Scholar
  34. D. J. Weiss, R. Casaburi, R. Flannery, M. LeRoux-Williams, and D. P. Tashkin, “A placebo-controlled, randomized trial of mesenchymal stem cells in COPD,” Chest, vol. 143, no. 6, pp. 1590–1598, 2013. View at Publisher · View at Google Scholar
  35. D. J. Weiss, L. A. Ortiz, A. Panoskaltsis-Mortari, and D. J. Prockop, “Stem cells and cell therapies in lung biology and lung diseases,” Proceedings of the American Thoracic Society, vol. 5, pp. 637–667, 2008. View at Google Scholar
  36. M. A. Matthay, B. T. Thompson, E. J. Read et al., “Therapeutic potential of mesenchymal stem cells for severe acute lung injury,” Chest, vol. 138, no. 4, pp. 965–972, 2010. View at Publisher · View at Google Scholar
  37. A. Krasnodembskaya, Y. Song, X. Fang et al., “Antibacterial effect of human mesenchymal stem cells is mediated in part from secretion of the antimicrobial peptide LL-37,” Stem Cells, vol. 28, no. 12, pp. 2229–2238, 2010. View at Publisher · View at Google Scholar
  38. T. L. Bonfield, M. T. Nolan-Koloze, D. P. Lennon, and A. I. Caplan, “Defining human mesenchymal stem cell efficacy in vivo,” Journal of Inflammation, vol. 7, pp. 51–63, 2010. View at Publisher · View at Google Scholar
  39. T. L. Bonfield, M.T. Koloze, D. P. Lennon, B. Zuchowski, S. E. Yang, and A. I. Caplan, “Human mesenchymal stem cells suppress chronic airway inflammation in the murine ovalbumin asthma model,” The American Journal of Physiology—Lung Cellular and Molecular Physiology, vol. 299, no. 6, pp. L760–L770, 2010. View at Publisher · View at Google Scholar
  40. Y. Sun and M. Deng, “Human pluripotent stem cell-derived mesenchymal stem cells prevent allergic airway inflammation in mice,” Stem Cells, vol. 30, no. 12, pp. 2692–2699, 2012. View at Google Scholar
  41. J. M. Brown, K. Nemeth, N. M. Kushnir-Sukhov, D. D. Metcalfe, and E. Mezey, “Bone marrow stromal cells inhibit mast cell function via a COX2-dependent mechanism,” Clinical and Experimental Allergy, vol. 41, no. 4, pp. 526–534, 2011. View at Publisher · View at Google Scholar · View at Scopus