Migration, Proliferation, and Differentiation of Cord Blood Mesenchymal Stromal Cells Treated with Histone Deacetylase Inhibitor Valproic Acid

<table>VPA exerts different effects on MSC proliferation and expression of pluripotency markers. (a) Cell proliferation was assayed by measuring the intracellular ATP released by CB-derived MSC after pretreatment with or without (control) 1, 5, or 10 mM VPA. The experiment was performed twice using 6 replicate wells per condition, and <svg height="13.95" id="M10" style="vertical-align:-0.30096pt" version="1.1" viewbox="0 0 66.324997 13.95" width="66.324997" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
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</svg> indicates statistically significant difference relative to control. (b) The expression of the pluripotency genes SOX2 and Oct-4 was evaluated by qRT-PCR using 18S mRNA as internal calibrator. The data is representative of two independent experiments and <svg height="13.95" id="M11" style="vertical-align:-0.30096pt" version="1.1" viewbox="0 0 66.324997 13.95" width="66.324997" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
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</svg> indicates statistically significant difference relative to control.</table>

Stem Cells International

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Figure 4

Figure 4: Migration, Proliferation, and Differentiation of Cord Blood Mesenchymal Stromal Cells Treated with Histone Deacetylase Inhibitor Valproic Acid 

Figure 4 | Migration, Proliferation, and Differentiation of Cord Blood Mesenchymal Stromal Cells Treated with Histone Deacetylase Inhibitor Valproic Acid 