Prognostic Value of Glioma Cancer Stem Cell Isolation in Survival of Primary Glioblastoma Patients

Table 2

Demographic characteristics of the pGBM patient.

Characteristics	gCSCs positive	gCSCs negative	value^*
	Age (years)				0.188
Median
Range	11–72	28–82
Sex (number [%])			0.653
Male	8 (53%)	11 (46%)
Female	7 (47%)	13 (54%)
Mean follow-up (months)			0.225
Pathological diagnosis	Primary glioblastoma	Primary glioblastoma
Treatment	Surgery + Stupp’s regimen [19]	Surgery + Stupp’s regimen [19]
Extent of surgery (number [%])
Total resection	10 (67%)	14 (58%)	0.636
Subtotal resection	4 (27%)	8 (33%)
Partial resection	1 (7%)	2 (8%)
Recurrences (number [%])	11 (73%)	12 (50%)	0.192
Treatment of recurrences (number [%])
Radiation therapy	1 (9%)	0 (0%)
Adjuvant temozolomide	6 (55%)	10 (83%)
None	4 (36%)	2 (17%)
1p 19q codeletion by FISH	1 (7%)	0 (0%)	0.385
MGMT methylation by PCR	7 (47%)	11 (45%)	1.000

pGBM: primary glioblastoma; gCSCs: glioma cancer stem cells; MGMT: O-6-methylguanine-DNA methyltransferase. By Mann-Whitney test for continuous variables and by Fisher’s exact test for categorical variables.