Stimulation of Neural Stem Cell Proliferation by Inhibition of Phosphodiesterase 5

Figure 3

T0156 or zaprinast, but not sildenafil, increased ERK1/2 phosphorylation following 2 h of treatment. Phospho-ERK1/2 levels following treatment with 1 μM T0156 (a), 1 μM sildenafil (b), and 10 μM zaprinast (c) for 2 h were assessed by Western blot. Representative images are shown. Data are expressed as means ± SEM of at least 5 independent experiments. Two-tailed 𝑡-test, *𝑃<0.05 and **𝑃<0.01, significantly different from control.

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