Stimulation of Neural Stem Cell Proliferation by Inhibition of Phosphodiesterase 5
Figure 6
Inhibition of PKG prevented the phosphorylation of ERK1/2 by treatment with T0156 or zaprinast. Levels of phospho-ERK1/2 following treatment with 1 μM KT5823 and 1 μM T0156 (a), 1 μM sildenafil (b), and 10 μM zaprinast (c) for 2 h were assessed by Western blot. Representative images are shown. Data are expressed as means ± SEM of at least 4 independent experiments. One-way ANOVA (Bonferroni’s post-test), *, significantly different from control.
