Stimulation of Neural Stem Cell Proliferation by Inhibition of Phosphodiesterase 5

Table 1

PDE5 inhibitors increased the levels of cGMP in SVZ cells.

Treatment	cGMP levels (fmol/10^6 cells)
Control	7.4±0.9
T0156	29.7±4.2^∗
Sildenafil	28.8±5.1^∗
Zaprinast	33.1±6.1^∗∗

Cells were treated for 6 h with 1 µM T0156, 1 µM sildenafil, or 10 µM zaprinast and then lysed to measure the levels of cGMP. Data are expressed as means ± SEM of 4 independent experiments. One-way ANOVA (Dunnett’s post-test), ^∗𝑃<0.05 and ^∗∗𝑃<0.01, significantly different from control.