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Stem Cells International
Volume 2014, Article ID 917168, 7 pages
http://dx.doi.org/10.1155/2014/917168
Research Article

Effects of Toll-Like Receptors 3 and 4 in the Osteogenesis of Stem Cells

Department of Orthopedics, Affiliated Hospital of Jiangsu University, 438 Jiefang Road, Zhenjiang, Jiangsu 212000, China

Received 9 August 2014; Revised 16 November 2014; Accepted 1 December 2014; Published 25 December 2014

Academic Editor: Leonard M. Eisenberg

Copyright © 2014 Chen Qi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. Z. Chen, C. Wu, W. Gu, T. Klein, R. Crawford, and Y. Xiao, “Osteogenic differentiation of bone marrow MSCs by β-tricalcium phosphate stimulating macrophages via BMP2 signalling pathway,” Biomaterials, vol. 35, no. 5, pp. 1507–1518, 2014. View at Publisher · View at Google Scholar · View at Scopus
  2. R. Budiraharjo, K. G. Neoh, and E.-T. Kang, “Enhancing bioactivity of chitosan film for osteogenesis and wound healing by covalent immobilization of BMP-2 or FGF-2,” Journal of Biomaterials Science, vol. 24, no. 6, pp. 645–662, 2013. View at Publisher · View at Google Scholar · View at Scopus
  3. J.-E. Huh and S. Y. Lee, “IL-6 is produced by adipose-derived stromal cells and promotes osteogenesis,” Biochimica et Biophysica Acta (BBA)—Molecular Cell Research, vol. 1833, no. 12, pp. 2608–2616, 2013. View at Publisher · View at Google Scholar · View at Scopus
  4. R. Song, Q. Zeng, L. Ao et al., “Biglycan induces the expression of osteogenic factors in human aortic valve interstitial cells via toll-like receptor-2,” Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 32, no. 11, pp. 2711–2720, 2012. View at Publisher · View at Google Scholar · View at Scopus
  5. M. Pevsner-Fischer, V. Morad, M. Cohen-Sfady et al., “Toll-like receptors and their ligands control mesenchymal stem cell functions,” Blood, vol. 109, no. 4, pp. 1422–1432, 2007. View at Publisher · View at Google Scholar · View at Scopus
  6. G. E. Glass, J. K. Chan, A. Freidin, M. Feldmann, N. J. Horwood, and J. Nanchahal, “TNF-α promotes fracture repair by augmenting the recruitment and differentiation of muscle-derived stromal cells,” Proceedings of the National Academy of Sciences of the United States of America, vol. 108, no. 4, pp. 1585–1590, 2011. View at Publisher · View at Google Scholar · View at Scopus
  7. P. M. Mountziaris and A. G. Mikos, “Modulation of the inflammatory response for enhanced bone tissue regeneration,” Tissue Engineering Part B: Reviews, vol. 14, no. 2, pp. 179–186, 2008. View at Publisher · View at Google Scholar · View at Scopus
  8. G. Raicevic, M. Najar, K. Pieters et al., “Inflammation and toll-like receptor ligation differentially affect the osteogenic potential of human mesenchymal stromal cells depending on their tissue origin,” Tissue Engineering Part A, vol. 18, no. 13-14, pp. 1410–1418, 2012. View at Publisher · View at Google Scholar · View at Scopus
  9. R. S. Waterman, S. L. Tomchuck, S. L. Henkle, and A. M. Betancourt, “A new mesenchymal stem cell (MSC) paradigm: polarization into a pro-inflammatory MSC1 or an immunosuppressive MSC2 phenotype,” PLoS ONE, vol. 5, no. 4, Article ID e10088, 2010. View at Publisher · View at Google Scholar · View at Scopus
  10. G. S. Stein, J. B. Lian, J. L. Stein, A. J. Van Wijnen, and M. Montecino, “Transcriptional control of osteoblast growth and differentiation,” Physiological Reviews, vol. 76, no. 2, pp. 593–629, 1996. View at Google Scholar · View at Scopus
  11. V. Krishnan, H. U. Bryant, and O. A. MacDougald, “Regulation of bone mass by Wnt signaling,” The Journal of Clinical Investigation, vol. 116, no. 5, pp. 1202–1209, 2006. View at Publisher · View at Google Scholar · View at Scopus
  12. A. Lipton and C. Goessl, “Clinical development of anti-RANKL therapies for treatment and prevention of bone metastasis,” Bone, vol. 48, no. 1, pp. 96–99, 2011. View at Publisher · View at Google Scholar · View at Scopus
  13. J. E. Huh, J. Y. Choi, Y. O. Shin et al., “Arginine enhances osteoblastogenesis and inhibits adipogenesis through the regulation of Wnt and NFATc signaling in human mesenchymal stem cells,” International Journal of Molecular Sciences, vol. 15, no. 7, pp. 13010–13029, 2014. View at Publisher · View at Google Scholar
  14. J. Chen, X. Tu, E. Esen et al., “WNT7B promotes bone formation in part through mTORC1,” PLoS Genetics, vol. 10, no. 1, Article ID e1004145, 2014. View at Publisher · View at Google Scholar · View at Scopus
  15. A. Smajilagić, M. Aljičević, A. Redžić, S. Filipović, and A. C. Lagumdžija, “Rat bone marrow stem cells isolation and culture as a bone formative experimental system,” Bosnian Journal of Basic Medical Sciences, vol. 13, no. 1, pp. 27–30, 2013. View at Google Scholar · View at Scopus
  16. W. Wang, Z. Pan, X. Hu, Z. Li, Y. Zhao, and A.-X. Yu, “Vacuum-assisted closure increases ICAM-1, MIF, VEGF and collagen I expression in wound therapy,” Experimental and Therapeutic Medicine, vol. 7, no. 5, pp. 1221–1226, 2014. View at Publisher · View at Google Scholar · View at Scopus
  17. L. Passi-Even, D. Gazit, and I. Bab, “Ontogenesis of ultrastructural features during osteogenic differentiation in diffusion chamber cultures of marrow cells,” Journal of Bone and Mineral Research, vol. 8, no. 5, pp. 589–595, 1993. View at Google Scholar · View at Scopus
  18. C. Chenu, S. Colucci, M. Grano et al., “Osteocalcin induces chemotaxis, secretion of matrix proteins, and calcium- mediated intracellular signaling in human osteoclast-like cells,” The Journal of Cell Biology, vol. 127, no. 4, pp. 1149–1158, 1994. View at Publisher · View at Google Scholar · View at Scopus
  19. J. Glowacki, C. Rey, M. J. Glimcher, K. A. Cox, and J. Lian, “A role for osteocalcin in osteoclast differentiation,” Journal of Cellular Biochemistry, vol. 45, no. 3, pp. 292–302, 1991. View at Publisher · View at Google Scholar · View at Scopus
  20. D. Nam, E. Mau, Y. Wang et al., “T-lymphocytes enable osteoblast maturation via IL-17F during the early phase of fracture repair,” PLoS ONE, vol. 7, no. 6, Article ID e40044, 2012. View at Publisher · View at Google Scholar · View at Scopus
  21. L. C. Gerstenfeld, T.-J. Cho, T. Kon et al., “Impaired fracture healing in the absence of TNF-α signaling: the role of TNF-α in endochondral cartilage resorption,” Journal of Bone and Mineral Research, vol. 18, no. 9, pp. 1584–1592, 2003. View at Publisher · View at Google Scholar · View at Scopus
  22. X. Yang, B. F. Ricciardi, A. Hernandez-Soria, Y. Shi, N. Pleshko Camacho, and M. P. G. Bostrom, “Callus mineralization and maturation are delayed during fracture healing in interleukin-6 knockout mice,” Bone, vol. 41, no. 6, pp. 928–936, 2007. View at Publisher · View at Google Scholar · View at Scopus
  23. S. Boonrungsiman, E. Gentleman, R. Carzaniga et al., “The role of intracellular calcium phosphate in osteoblast-mediated bone apatite formation,” Proceedings of the National Academy of Sciences of the United States of America, vol. 109, no. 35, pp. 14170–14175, 2012. View at Publisher · View at Google Scholar · View at Scopus
  24. R. Buchet, S. Pikula, D. Magne, and S. Mebarek, “Isolation and characteristics of matrix vesicles,” Methods in Molecular Biology, vol. 1053, pp. 115–124, 2013. View at Publisher · View at Google Scholar · View at Scopus
  25. C. Wennberg, L. Hessle, P. Lundberg et al., “Functional characterization of osteoblasts and osteoclasts from alkaline phosphatase knockout mice,” Journal of Bone and Mineral Research, vol. 15, no. 10, pp. 1879–1888, 2000. View at Publisher · View at Google Scholar · View at Scopus
  26. D. A. Glass II and G. Karsenty, “In vivo analysis of Wnt signaling in bone,” Endocrinology, vol. 148, no. 6, pp. 2630–2634, 2007. View at Publisher · View at Google Scholar · View at Scopus
  27. S. L. Holmen, C. R. Zylstra, A. Mukherjee et al., “Essential role of β-catenin in postnatal bone acquisition,” The Journal of Biological Chemistry, vol. 280, no. 22, pp. 21162–21168, 2005. View at Publisher · View at Google Scholar · View at Scopus
  28. H. Yi, A. K. Patel, C. P. Sodhi, D. J. Hackam, and A. S. Hackam, “Novel role for the innate immune receptor toll-like receptor 4 (TLR4) in the regulation of the wnt signaling pathway and photoreceptor apoptosis,” PLoS ONE, vol. 7, no. 5, Article ID e36560, 2012. View at Publisher · View at Google Scholar · View at Scopus