Long-Term Quantitative Biodistribution and Side Effects of Human Mesenchymal Stem Cells (hMSCs) Engraftment in NOD/SCID Mice following Irradiation
Histological examination of radiation exposed tissues by HES staining and human beta-2-microglobulin immunostaining in spleen and kidney. (a) illustrates a spleen of nonirradiated mice (control), (b) shows cell depletion 15 days after total body irradiation. The human cells expressing the human beta-2-microglobulin are stained in red. hMSCs migrated around the vascular axis (f), in functional structure such as glomerulus (e). Into glomerulus human cells have integrated both unitary structures: the glomerulus (e) and vascular endothelial system of this organ (g).