Stem Cells International / 2014 / Article / Tab 5

Research Article

Long-Term Quantitative Biodistribution and Side Effects of Human Mesenchymal Stem Cells (hMSCs) Engraftment in NOD/SCID Mice following Irradiation

Table 5

Histological analysis of tissue at 120 days after total body irradiation at 3.5 Gray in hMSC injected mice.

Organs Positive organsNegative organs
Number of miceTumourTissueNumber of miceTumourTissue
DisruptionAbnormalityDisruptionAbnormality

Brain1Neg.Neg.Neg.9Neg.Neg.Neg.
Heart4Neg.Neg.Neg.6Neg.Neg.Neg.
Lung2Neg.Neg.Neg.8Neg.Neg.Neg.
Liver0NDNDND10Neg.Neg.Neg.
Spleen2Neg.Neg.Neg.8Neg.Neg.Neg.
Kidney 2Neg.Neg.Neg.8Neg.Neg.Neg.
Abdominal area
 Muscle1Neg.Neg.Neg.5Neg.Neg.Neg.
 Stomach0NDNDND8Neg.Neg.Neg.
 Duodenum1Neg.Neg.Neg.9Neg.Neg.Neg.
 Jejunum1Neg.Neg.Neg.9Neg.Neg.Neg.
 Ileum1Neg.Neg.Neg.9Neg.Neg.Neg.
 Cecum1Neg.Neg.Neg.9Neg.Neg.Neg.
 Colon proximal 3Neg.Neg.Neg.7Neg.Neg.Neg.
 Colon distal 2Neg.Neg.Neg.8Neg.Neg.Neg.
Posterior leg (right)
 Skin0NDNDND10Neg.Neg.Neg.
 Muscle 1Neg.Neg.Neg.7Neg.Neg.Neg.
 Bone 5Neg.Neg.Neg.5Neg.Neg.Neg.
 Bone marrow4Neg.Neg.Neg.5Neg.Neg.Neg.

Histological analysis of various radiation-induced tissue damage was performed on all organs collected (heart, lung, liver, kidney, spleen, stomach, intestine in its entirety, muscle and skin of the posterior femur of left leg, and the brain). No tissue damage or structural changes were observed in the studied organs.