Review Article
Neural Differentiation of Human Pluripotent Stem Cells for Nontherapeutic Applications: Toxicology, Pharmacology, and In Vitro Disease Modeling
Table 3
In vitro modeling of neurodegenerative and neurodevelopmental disorders with hPSCs-derived neuronal lineages.
| Disease model | Key references |
| Alzheimer’s disease | Israel et al. [84] |
| Huntington’s disease | An et al. [85] The HD iPSC Consortium [86] |
| Amyotrophic lateral sclerosis | Mitne-Neto et al. [87] |
| Autism spectrum disorder | Kim et al. [88] |
| Schizophrenia | Chiang et al. [89] Brennand et al. [90] |
| Rett syndrome | Ananiev et al. [91] Cheung et al. [92] Li et al. [93] Williams et al. [94] |
| Fragile X syndrome | Sheridan et al. [95] Bar-Nur et al. [96] Liu et al. [97] |
| Timothy syndrome |
Paşca et al. [98] Krey et al. [99] |
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