Immune Suppressive Effects of Tonsil-Derived Mesenchymal Stem Cells on Mouse Bone-Marrow-Derived Dendritic Cells

Figure 4

T-MSCs inhibited the release of GM-CSF, IL-6, MCP-1, and RANTES from mature DCs. (a) T cells were cocultured with mature DCs in the presence of T-MSCs. Conditioned medium was collected and subjected to Cytokine Array. (b) Plate arrangement of the Cytokine Array and cytokine spots, which show increased expression, are highlighted with a red box. (c) Expression changes were quantified and significant decreases in GM-CSF, RANTES, interleukin-6 (IL-6), and monocyte chemoattractant protein-1 (MCP-1) were observed when mature DCs and T cells were cocultured with T-MSCs.