The Role of Adipose-Derived Stem Cells in Breast Cancer Progression and Metastasis

Table 2

Relevant in vitro studies investigating the effects of ADSCs on breast cancer.

Reference	Year	ADSC origin	ADSC surface marker	BCC line	Effects on BCC
Trivanović et al.; [58]	2014	Human breast; (normal versus cancer-affected) and abdominal	CD44^+CD73^+CD90^+CD105^+; CD11a^−CD33^−CD45^−CD235a^−; HLA-DR^−CD34^±	MCF-7	Proliferation↑ (direct coculture); Proliferation↓; (indirect coculture); Different ADSCs had similar effects
Kucerova et al.; [23]	2013	Human lipoaspirates	CD29^+CD44^+CD90^+CD105^+; CD14^−CD34^−CD45^−	SKBR3	Proliferation↓, migration↑; EMT markers↑; BCC chemosensitivity↑
Lin et al.; [46]	2013	Human lipoaspirates	CD29^+CD44^+CD105^+; CD31^−CD34^−HLA-DR^−	MCF-7	Proliferation and migration↑; Cell-to-cell contact needed; Wnt pathway↑
Strong et al.; [72]	2013	Human abdominal; versus nonabdominal	n.s.	MCF-7, MDA-MB-231	Proliferation↑; Leptin/estrogen-dependent; Increased effect of abdominal ADSCs from obese (versus lean and nonabdominal ADSCs)
Zhang et al.; [50]	2013	Human breast (cancer-affected)	CD13^+CD29^+CD44^+CD71^+; CD105^+HLA-I^+; CD4^−CD10^−CD14^−CD34^−; CD38^−HLA-DR^−	MCF-7	Proliferation↑; Migration↑
Zhao et al.; [47]	2013	Human lipoaspirates; (abdominal)	CD29^+CD44^+CD105^+; CD34^−CD45^−	MCF-7	Migration↑; Angiogenesis↓; MMPs↑
Devarajan et al.; [70]	2012	Human whole fat	n.s.	4T1 (murine); BT-474, MCF-7, T47D	Proliferation↑, EMT markers↑; PDGF-dependent (paracrine)
Jotzu et al.; [109]	2011	Human whole fat	CD29^+CD44^+CD90^+CD105^+; CD14^−CD34^−CD45^−	MCF-7, MDA-MB-231	Migration and invasion↑; ADSCs differentiate to CAFs
Kucerova et al.; [93]	2011	Human lipoaspirates	CD44^+CD73^+CD90^+CD105^+; CD14^−CD34^−CD45^−	MCF-7, T47D, MDA-MB-361	BCC proliferation↑ (dose-dependent); Paracrine mechanism
Razmkhah et al.; [61]	2011	Human breast; (cancer-affected)	CD44^+CD105^+CD166^+; CD14^−CD34^−CD45^−	MCF-7	Anti-inflammatory cytokines↑; T regs↑
Yan et al.; [98]	2012	Human breast; (normal versus cancer-affected)	CD29^+CD73^+CD90^+CD105^+; CD166^+; CD31^−CD144^−CD14^−CD45^−; HLA-DR^−	MCF-7	Proliferation↑; (BC ADSCs > normal breast ADSCs); EGF/EGFR/Akt-dependent
Pinilla et al.; [38]	2009	Human abdominal	n.s.	MDA-MB-231	Proliferation↑, RANTES↑; Migration↑, MMPs↑
Welte et al.; [73]	2012	Human lipoaspirates; (abdominal)	CD44^+CD90^+CD105^+; CD11b^−CD14^−CD34^−CD45^−; HLA-DR^−	MCF-7, MDA-MB-231, T47D	ADSC migration towards BCCs; Migration and invasiveness↑; IL-8↑

ADSC: adipose-derived stem cell; BC: breast cancer; BCC: breast cancer cell; CAF: cancer-associated (myo) fibroblast; EMT: epithelial-to-mesenchymal transition; ER: estrogen receptor; Her2: human epidermal growth factor receptor 2; MMPs: matrix metalloproteinases; MPE: metastatic pleural effusion; n.s.: not specified; PR: progesterone receptor; T reg: regulatory T lymphocyte.