Intravenous Administration of Bone Marrow-Derived Mesenchymal Stem Cells Induces a Switch from Classical to Atypical Symptoms in Experimental Autoimmune Encephalomyelitis

Figure 2

Experimental autoimmune encephalomyelitis model (EAE). (a) EAE induction. C57BL/6 mice were subcutaneously injected with 50 μg of MOG_35–55, emulsified with CFA and Mycobacterium tuberculosis (4 mg/mL). 2 and 48 hrs later, mice were intraperitoneally injected with Pertussis toxin (350 ng/mL). MSCs (1 × 10⁶) were intravenously administrated either at the onset (), at peak of the disease (), or at the time of EAE stabilization (). After EAE induction, animal groups were evaluated daily for both clinical score and animal weight for a total of 50 days. (b-c) Representative photographs of EAE mice manifesting the distinctive classical (b) and atypical (c) signs of the disease and their respective clinical scores are shown.

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