Research Article
Intravenous Administration of Bone Marrow-Derived Mesenchymal Stem Cells Induces a Switch from Classical to Atypical Symptoms in Experimental Autoimmune Encephalomyelitis
Figure 3
MSCs injections at the onset and at the peak of disease induce an improvement of classical EAE. C57BL/6 mice were immunized with MOG35–55 to induce EAE and classical score was evaluated daily. MSCs (1 × 106) were intravenously injected either at (a, b) the onset of EAE symptoms (), (c, d) at the peak of the disease (), or (e, f) at the time of EAE stabilization (). Daily clinical score (a, c, e) and the area under curve (AUC) (b, d, f) parameters were evaluated after MSCs injection as described in Methods and AUC were plotted at specific time periods as indicated. Line curves and bars represent the mean ± SEM; statistical differences were calculated using Mann-Whitney test (), .
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