Research Article
Intravenous Administration of Bone Marrow-Derived Mesenchymal Stem Cells Induces a Switch from Classical to Atypical Symptoms in Experimental Autoimmune Encephalomyelitis
Figure 4
MSCs injections at the peak of EAE and at the time of EAE stabilization induce the appearance of atypical signs. EAE was induced on C57BL/6 mice by MOG35–55 immunization and both classical and nonclassical atypical scores were evaluated as described in Methods. (a) Incidence of classical versus atypical EAE was calculated as the percentage of EAE mice with atypical signs over EAE mice with classical phenotype at the end of the experiment. (b) Atypical cumulative scores were calculated for untreated EAE mice (EAE) and for EAE mice treated with MSCs at the onset (), at the peak (), and at the time of EAE stabilization (). Bars represent the mean ± SEM. Statistical differences were calculated using Mann-Whitney test (), .
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