Hematopoietic Stem and Immune Cells in Chronic HIV Infection

Figure 1

A trinity of cure by CD4 T-cell turnover. P21, cytokine, and immunotherapy can affect all three processes indicated by A, B, and C. Through cell renewal and turnover, one can regulate CD4 T-cell pool size, reprogram T-cell immune memory repertoire, and modulate immune activation and function thereby to reconstitute patient immunity towards an HIV cure.