Review Article

Umbilical Cord Tissue-Derived Cells as Therapeutic Agents

Table 1

Schematic summary of current data on the putative mechanisms of UC-derived cell action.

Objective of therapyPossible influence References
Direct tissue remodelling (including 2D, 3D biomaterials) “Type-like” cell effects Paracrine mechanisms

Liver++Campard et al., 2008 [35];
Tsai et al., 2009 [36];
Anzalone et al., 2010 [37];
Shi et al., 2012 [38];
Wang et al., 2013 [39]

Heart and cardiovascular system++Kadner et al., 2002 [40];
Corrao et al., 2013 [41];
López et al., 2013 [42];
Nascimento et al., 2014 [43]

Kidneys and excretory system+Du et al., 2012 [44];
Song et al., 2014 [45]

Central and peripheral nervous systems+++Weiss et al., 2003 [46];
Fu et al., 2004 [47];
Fu et al., 2006 [48];
Weiss et al., 2006 [49];
Joyce et al., 2010 [50];
Matsuse et al., 2010 [51];
Carvalho et al., 2011 [52];
Dongmei et al., 2011 [53]
Zhang et al., 2011 [54];
Dalous et al., 2012 [55];
Hsieh et al., 2013 [56];
Taran et al., 2014 [57]

Cartilage++Wang et al., 2009 [58];
Arufe et al., 2011 [59];
lo Iacono et al., 2011 [60]

Metabolic regulation, immune system, and autoimmune diseases+Tyndall and Uccelli, 2009 [61];
Mazzini et al., 2010 [62];
Uccelli and Prockop, 2010 [63];
Liu et al., 2014 [64]

Skin++Shohara et al., 2012 [65];
Arno et al., 2014 [66]

Lungs and respiratory system+Lee et al., 2011 [67];
Weiss, 2014 [68]