Bcl-xL Genetic Modification Enhanced the Therapeutic Efficacy of Mesenchymal Stem Cell Transplantation in the Treatment of Heart Infarction

Figure 6

Antiapoptotic effect of hBcl-xL-MSCs in vivo. ((a)–(c)) TUNEL assay was performed at 4 weeks after transplantation of medium (a), vector-MSCs (b), or hBcl-xL-MSCs (c). TUNEL-positive cells were defined as cells with clear brown-colored nuclear labeling. (d) The apoptotic rate was presented as the ratio of the area of TUNEL-positive cell nuclei and the area of total cell nuclei. Values are mean ± SD (, ). TUNEL: terminal deoxynucleotidyl transferase-mediated dUTP end labeling. Scale bar represents 50 μm.

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