Bcl-xL Genetic Modification Enhanced the Therapeutic Efficacy of Mesenchymal Stem Cell Transplantation in the Treatment of Heart Infarction

Figure 7

hBcl-xL-MSCs promoted angiogenesis and prevented scar formation in infarcted heart. ((a)–(c)) Evaluation of capillary density by von Willebrand factor staining at 4 weeks after transplantation of medium (a), vector-MSCs (b), or hBcl-xL-MSCs (c). ((d)–(f)) Assessment of scar formation by Trichrome-Masson staining at 4 weeks after medium (d), vector-MSCs (e), or hBcl-xL-MSCs (f) transplantation. (g) Capillary density was presented as the number of vessels per high-power field. (h) Scar size was presented as the percentage of the collagen deposition area to the whole section area of the left ventricle. Values are mean ± SD (, , ). Scale bar represents 50 μm (c) and 1 mm (f), respectively.

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