Protective Effect of Neuropeptide Substance P on Bone Marrow Mesenchymal Stem Cells against Apoptosis Induced by Serum Deprivation

<div>Effect of SP on the nuclear translocation of <i>β</i>-catenin in BMSCs. SP exhibited a stable ability to activate <i>β</i>-catenin nuclear translocation. In BMSCs, nuclear <i>β</i>-catenin was not evident, whereas its nuclear localization was clearly observed following SP treatment, as indicated by FITC-linked <i>β</i>-catenin (indicated by the arrow in the SP group). With combined NK-1 antagonist and SP treatment, nuclei appeared relatively dark (indicated by the arrow in the SP + NK-1 antagonist group).</div>

Stem Cells International

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Figure 4

Figure 4: Protective Effect of Neuropeptide Substance P on Bone Marrow Mesenchymal Stem Cells against Apoptosis Induced by Serum Deprivation 