Review Article
Recent Advances in Hydroxyapatite Scaffolds Containing Mesenchymal Stem Cells
Table 3
Summary of references for dual differentiation.
| Source of stem cells | Material used | Results | Study/reference |
| ASCs | Fibronectin/HA | ↑ osteopontin, ↑ Runx2, ↑ osteocalcin, ↑ osteonectin, ↑ collagen 1, ↓ peroxisome proliferator-activated factor gamma | Gardin et al. 2012/[28] | hMSC | HA/Beta-TCP with hPL coating | ↑ PGF, ↑ VEGF, ↑ ALP Activity |
Leotot et al. 2013/[29] | hMSC | HA/Beta-TCP with hPL media | ↑ mineralization | Chen et al. 2012/[30] | MMEC, BMSCs | Silk/HA | MSC only: ↑ collagen I staining, Von Kossa staining, osteocalcin staining Coculture: vascular network-like formation | Sun et al. 2012/[31] | Chondrocytes/hMSCs | Methacrylated hyaluronic acid/methacrylated hydroxyapatite | Positive calcification staining and extracellular matrix development | Galperin et al. 2013/[32] | BMSCs | Collagen/HA | High HA/collagen is more osteogenic while low HA/collagen induces chondrogenic differentiation | Zhou et al. 2011/[33] |
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