Recent Advances in Hydroxyapatite Scaffolds Containing Mesenchymal Stem Cells

Table 3

Summary of references for dual differentiation.

Source of stem cells	Material used	Results	Study/reference
ASCs	Fibronectin/HA	↑ osteopontin, ↑ Runx2, ↑ osteocalcin, ↑ osteonectin, ↑ collagen 1, ↓ peroxisome proliferator-activated factor gamma	Gardin et al. 2012/[28]
hMSC	HA/Beta-TCP with hPL coating	↑ PGF, ↑ VEGF, ↑ ALP Activity	Leotot et al. 2013/[29]
hMSC	HA/Beta-TCP with hPL media	↑ mineralization	Chen et al. 2012/[30]
MMEC, BMSCs	Silk/HA	MSC only: ↑ collagen I staining, Von Kossa staining, osteocalcin staining; Coculture: vascular network-like formation	Sun et al. 2012/[31]
Chondrocytes/hMSCs	Methacrylated hyaluronic acid/methacrylated hydroxyapatite	Positive calcification staining and extracellular matrix development	Galperin et al. 2013/[32]
BMSCs	Collagen/HA	High HA/collagen is more osteogenic while low HA/collagen induces chondrogenic differentiation	Zhou et al. 2011/[33]