Table of Contents Author Guidelines Submit a Manuscript
Stem Cells International
Volume 2015, Article ID 318269, 7 pages
http://dx.doi.org/10.1155/2015/318269
Research Article

Efficacy of Surgery Combined with Autologous Bone Marrow Stromal Cell Transplantation for Treatment of Intracerebral Hemorrhage

1Department of Neurosurgery, Liaocheng People’s Hospital of Taishan Medical University, Liaocheng 252000, China
2Neurological Laboratory, Liaocheng People’s Hospital of Taishan Medical University, Liaocheng 252000, China
3Department of Hematology, Liaocheng People’s Hospital of Taishan Medical University, Liaocheng 252000, China

Received 8 October 2014; Revised 30 December 2014; Accepted 13 January 2015

Academic Editor: Abhijit De

Copyright © 2015 Jianxin Zhu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Bone marrow stromal cells (BMSCs) may differentiate into nerve cells under a certain condition; however, the clinical application for treating nervous system disease remains unclear. The aim is to assess the safety profile, feasibility, and effectiveness of surgery combined with autologous BMSCs transplantation for treating ICH. 206 ICH patients who had received surgical procedure were divided into transplantation () or control group (). For transplantation group, BMSCs were injected into the perihemorrhage area in the base ganglia through an intracranial drainage tube 5.5 (3.01–6.89) days after surgery, followed by a second injection into the subarachnoid space through lumbar puncture 4 weeks later. Neurologic impairment and daily activities were assessed with National Institute Stroke Scale (NIHSS), Barthel index, and Rankin scale before transplantation and 6 months and 12 months after transplantation. Our results revealed that, compared with control group, NIHSS score and Rankin scale were both significantly decreased but Barthel index was increased in transplantation group after 6 months. Interestingly, no significant difference was observed between 12 months and 6 months. No transplantation-related adverse effects were investigated during follow-up assessments. Our findings suggest that surgery combined with autologous BMSCs transplantation is safe for treatment of ICH, providing short-term therapeutic benefits.