Research Article
HLA-E: Presentation of a Broader Peptide Repertoire Impacts the Cellular Immune Response—Implications on HSCT Outcome
Figure 4
Models of noncanonical self-peptides bound to HLA-E show highly diverse confirmation resulting in distinct accessible surface areas. (a) The HLA-E crystal structure with the VMAPRTLFL (orange) peptide (PDB: 3CDG) was used as a template for modelling the peptides into the PBR of the HLA-E molecule (raspberry). (b) The SKGKIYPVGY (olive) peptide shows only minimal surface area that protrudes out the PBR compared to (c) DVHDGKVVSTHEQ (teal) that strongly forms a bulgy structure that provides large parts of its accessible surface to solvent. This is also the case for the peptides (d) LGHPDTLNQGEFKEL (marine blue) and (e) LVDSGAQVSVVHPNL (cyan).
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