Transdifferentiation of Human Hair Follicle Mesenchymal Stem Cells into Red Blood Cells by OCT4

Figure 5

Enucleation and maturation of hHFMSC-derived erythroblasts in vitro. (a) hHFMSC-derived erythrocytes were cytospun and stained with Wright-Giemsa dye and compared with red blood cells from human blood. Scale bar represents 20 μm. (b) Cell stained with monoclonal antibody against hemoglobin β-chain (left) or γ-chain (right). (c) The frequencies of generated RBCs expressing β-chain and γ-chain hemoglobin were presented by the average ratios of positive cells to total cells from more than 3 fields under microscope.

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