WNT/β-Catenin Signaling Is Required for Integration of CD₂₄₊ Renal Progenitor Cells into Glycerol-Damaged Adult Renal Tubules

Figure 5

β-catenin/TCF signaling in CD₂₄₊ embryonic kidney cells in vitro. (a) CD₂₄₊ cells isolated from E15 kidney of mice bearing the β-catenin/TCF-lacZ transgene show minimal β-galactosidase activity (blue) in baseline monolayer culture. (b) About 40% of CD₂₄₊ cells exposed to murine L-cells expressing Wnt3a showed canonical β-catenin/TCF signaling. (c) CD₂₄₊ cells exposed to ureteric bud cells isolated by FACS from E15 Hoxb7-GFP mice showed similar canonical β-catenin/TCF signaling. Scale bar: 50 μm.

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