Particle Radiation-Induced Nontargeted Effects in Bone-Marrow-Derived Endothelial Progenitor Cells

Figure 5

Cumulative levels of inflammatory cytokines and chemokines are significantly increased in ⁵⁶Fe-IR conditioned medium. Graphic representation of IR-induced increase in the cumulative concentration (pg/mL) of cytokines, chemokines, and growth factors in CM from 15 cGy ⁵⁶Fe-IR BM-EPCs in vitro at 2, 5 and 24 hours post-IR for (a) IL-1α, (b) IL-1β, (c) G-CSF, (d) GM-CSF, (e) MCP-1, (f) MIP-1α, (g) SCF, and (h) Rantes. Graphs represent mean ± SEM of the pooled data from 3 independent biological samples/experiments. Statistical significance was assigned when .

(a)  

(b)

(c)

(d)

(e)

(f)

(g)

(h)