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Stem Cells International
Volume 2015 (2015), Article ID 613045, 7 pages
http://dx.doi.org/10.1155/2015/613045
Research Article

Multiple Myeloma Patients at Various Cytogenetic Risks Benefit Differently from Autologous Stem Cell Transplantation as a Consolidation Therapy

Department of Hematology, The Myeloma and Lymphoma Center, Changzheng Hospital, The Second Military Medical University, 415 Fengyang Road, Shanghai 200003, China

Received 28 October 2014; Revised 14 December 2014; Accepted 5 January 2015

Academic Editor: Boon Chin Heng

Copyright © 2015 Tianmei Zeng et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. J. F. San-Miguel and M.-V. Mateos, “Can multiple myeloma become a curable disease?” Haematologica, vol. 96, no. 9, pp. 1246–1248, 2011. View at Publisher · View at Google Scholar · View at Scopus
  2. P. Moreau and S. Minvielle, “Multiple myeloma: so much progress, but so many unsolved questions,” Haematologica, vol. 98, no. 4, pp. 487–489, 2013. View at Publisher · View at Google Scholar · View at Scopus
  3. P. Moreau, H. Avet-Loiseau, J. L. Harousseau, and M. Attal, “Current trends in autologous stem-cell transplantation for myeloma in the era of novel therapies,” Journal of Clinical Oncology, vol. 29, no. 14, pp. 1898–1906, 2011. View at Publisher · View at Google Scholar · View at Scopus
  4. J. Du, J. Huo, J. Shi et al., “Polymorphisms of nuclear factor-κB family genes are associated with development of multiple myeloma and treatment outcome in patients receiving bortezomib-based regimens,” Haematologica, vol. 96, no. 5, pp. 729–737, 2011. View at Publisher · View at Google Scholar · View at Scopus
  5. R. Siegel, E. Ward, O. Brawley, and A. Jemal, “Cancer statistics, 2011: the impact of eliminating socioeconomic and racial disparities on premature cancer deaths,” CA: Cancer Journal for Clinicians, vol. 61, no. 4, pp. 212–236, 2011. View at Publisher · View at Google Scholar · View at Scopus
  6. L.-L. Zhou, Z.-G. Yuan, W.-J. Fu et al., “Clinical effects of autologous stem cell transplantation as consolidation treatment in 70 multiple myeloma patients: a case-controlled study,” Chinese Medical Journal, vol. 124, no. 19, pp. 2975–2980, 2011. View at Publisher · View at Google Scholar · View at Scopus
  7. D. Tan, W. J. Chng, T. Chou et al., “Management of multiple myeloma in asia: resource-stratified guidelines,” The Lancet Oncology, vol. 14, no. 12, pp. e571–e581, 2013. View at Publisher · View at Google Scholar · View at Scopus
  8. W. J. Chng, A. Dispenzieri, C.-S. Chim et al., “IMWG consensus on risk stratification in multiple myeloma,” Leukemia, vol. 28, no. 2, pp. 269–277, 2014. View at Publisher · View at Google Scholar · View at Scopus
  9. B. G. M. Durie, J. L. Harousseau, J. S. Miguel et al., “International uniform response criteria for multiple myeloma,” Leukemia, vol. 20, no. 9, pp. 1467–1473, 2006. View at Publisher · View at Google Scholar · View at Scopus
  10. D. M. Benson Jr., P. J. Elder, T. S. Lin et al., “High-dose melphalan versus busulfan, cyclophosphamide, and etoposide as preparative regimens for autologous stem cell transplantation in patients with multiple myeloma,” Leukemia Research, vol. 31, no. 8, pp. 1069–1075, 2007. View at Publisher · View at Google Scholar · View at Scopus
  11. S. V. Rajkumar, J.-L. Harousseau, B. Durie et al., “Consensus recommendations for the uniform reporting of clinical trials: report of the International Myeloma Workshop Consensus Panel 1,” Blood, vol. 117, no. 18, pp. 4691–4695, 2011. View at Publisher · View at Google Scholar · View at Scopus
  12. M. T. Petrucci, A. Levi, S. Bringhen et al., “Bortezomib, melphalan, and prednisone in elderly patients with relapsed/refractory multiple myeloma: a multicenter, open label phase 1/2 study,” Cancer, vol. 119, no. 5, pp. 971–977, 2013. View at Publisher · View at Google Scholar · View at Scopus
  13. J. Koreth, C. S. Cutler, B. Djulbegovic et al., “High-dose therapy with single autologous transplantation versus chemotherapy for newly diagnosed multiple myeloma: a systematic review and meta-analysis of randomized controlled trials,” Biology of Blood and Marrow Transplantation, vol. 13, no. 2, pp. 183–196, 2007. View at Publisher · View at Google Scholar · View at Scopus
  14. M. Cavo, P. Tacchetti, F. Patriarca et al., “Bortezomib with thalidomide plus dexamethasone compared with thalidomide plus dexamethasone as induction therapy before, and consolidation therapy after, double autologous stem-cell transplantation in newly diagnosed multiple myeloma: a randomised phase 3 study,” The Lancet, vol. 376, no. 9758, pp. 2075–2085, 2010. View at Publisher · View at Google Scholar · View at Scopus
  15. J.-L. Harousseau, M. Attal, H. Avet-Loiseau et al., “Bortezomib plus dexamethasone is superior to vincristine plus doxorubicin plus dexamethasone as induction treatment prior to autologous stem-cell transplantation in newly diagnosed multiple myeloma: results of the IFM 2005-01 phase III trial,” Journal of Clinical Oncology, vol. 28, no. 30, pp. 4621–4629, 2010. View at Publisher · View at Google Scholar · View at Scopus
  16. P. Sonneveld, I. G. Schmidt-Wolf, B. van der Holt et al., “Bortezomib induction and maintenance treatment in patients with newly diagnosed multiple myeloma: results of the randomized phase III HOVON-65/GMMG-HD4 trial,” Journal of Clinical Oncology, vol. 30, no. 24, pp. 2946–2955, 2012. View at Publisher · View at Google Scholar
  17. A. Palumbo, F. Gay, P. Falco et al., “Bortezomib as induction before autologous transplantation, followed by lenalidomide as consolidation-maintenance in untreated multiple myeloma patients,” Journal of Clinical Oncology, vol. 28, no. 5, pp. 800–807, 2010. View at Publisher · View at Google Scholar
  18. C. B. Reeder, D. E. Reece, V. Kukreti et al., “Cyclophosphamide, bortezomib and dexamethasone induction for newly diagnosed multiple myeloma: high response rates in a phase II clinical trial,” Leukemia, vol. 23, no. 7, pp. 1337–1341, 2009. View at Publisher · View at Google Scholar · View at Scopus
  19. S. Z. Usmani, J. Crowley, A. Hoering et al., “Improvement in long-term outcomes with successive Total Therapy trials for multiple myeloma: are patients now being cured?” Leukemia, vol. 27, no. 1, pp. 226–232, 2013. View at Publisher · View at Google Scholar · View at Scopus
  20. A. Palumbo, S. Bringhen, A. M. Liberati et al., “Oral melphalan, prednisone, and thalidomide in elderly patients with multiple myeloma: updated results of a randomized controlled trial,” Blood, vol. 112, no. 8, pp. 3107–3114, 2008. View at Publisher · View at Google Scholar · View at Scopus
  21. P. M. Fayers, A. Palumbo, C. Hulin et al., “Thalidomide for previously untreated elderly patients with multiple myeloma: meta-analysis of 1685 individual patient data from 6 randomized clinical trials,” Blood, vol. 118, no. 5, pp. 1239–1247, 2011. View at Publisher · View at Google Scholar · View at Scopus
  22. M. Boccadoro, F. Cavallo, A. Nagler et al., “Melphalan/prednisone/lenalidomide (MPR) versus high-dose melphalan and autologous transplantation (MEL200) in newly diagnosed multiple myeloma (MM) patients: a phase III trial,” Journal of Clinical Oncology, vol. 29, supplement 15, 2011, 2011 ASCO Annual Meeting, Abstract no. 8020. View at Google Scholar
  23. S. K. Kumar, J. R. Mikhael, F. K. Buadi et al., “Management of newly diagnosed symptomatic multiple myeloma: updated Mayo Stratification of Myeloma and Risk-Adapted Therapy (mSMART) consensus guidelines,” Mayo Clinic Proceedings, vol. 84, no. 12, pp. 1095–1110, 2009. View at Publisher · View at Google Scholar · View at Scopus
  24. H. Avet-Loiseau, M. Attal, P. Moreau et al., “Genetic abnormalities and survival in multiple myeloma: the experience of the Intergroupe Francophone du Myélome,” Blood, vol. 109, no. 8, pp. 3489–3495, 2007. View at Publisher · View at Google Scholar · View at Scopus
  25. A. Hoering, J. Crowley, J. D. Shaughnessy Jr. et al., “Complete remission in multiple myeloma examined as time-dependent variable in terms of both onset and duration in Total Therapy protocols,” Blood, vol. 114, no. 7, pp. 1299–1305, 2009. View at Publisher · View at Google Scholar · View at Scopus