Neuroprotective and Antiapoptotic Activity of Lineage-Negative Bone Marrow Cells after Intravitreal Injection in a Mouse Model of Acute Retinal Injury

Figure 5

Effects of Lin⁻BMC transplantation on retinal morphology and the b-wave ERG amplitudes over time. The scotopic (a), mixed rod-cone (b), and photopic (c) response, as well as oscillatory potentials (d), were analyzed repeatedly on the same individual mice during the time of the experiment. The results are presented as the mean ± SD (). Representative in vivo SD-OCT images of the retina on the 7th and 28th day and at the 3rd month after injury showing a considerable improvement in the architecture of the outer and inner photoreceptor segments of the right eyes treated with Lin⁻BMCs (e). Quantitative comparative analysis of the total retinal thickness of the Lin⁻BMC-treated retinas compared with the control eyes (f). for the right eyes treated with Lin⁻BMCs versus the left eyes injected with PBS ().

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