Modulation of Hyaluronan Synthesis by the Interaction between Mesenchymal Stem Cells and Osteoarthritic Chondrocytes

Figure 2

Coculture upregulates hyaluronan production. Hyaluronan concentration (pg/mL/cell) after 3 and 6 days in monoculture (BM-MSCs and chondrocytes) or in coculture. Bars represent the mean and SEM; bars with gray line (expected coculture) show “expected hyaluronan production in coculture,” based on production of monoculture and cell number counted. Table shows the cell number in each group. The asterisk () indicates a significant () difference between cell culture groups based on a two-way ANOVA followed by Tukey’s posttest.