A Double-Switch Cell Fusion-Inducible Transgene Expression System for Neural Stem Cell-Based Antiglioma Gene Therapy
DoFIT mediates cell fusion-inducible transgene expression in vitro. (a) Low pH-dependent cell fusion between VSV-G-expressing NSC1 and U251 is examined by dual-color syncytia formation assays. (b) Transgene expression levels of cocultures between DoFIT-NSCs and U251 under different pH conditions are quantified by luciferase assays. Error bars: s.d. , .
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