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Stem Cells International
Volume 2015, Article ID 758706, 9 pages
http://dx.doi.org/10.1155/2015/758706
Research Article

Effects of Naringin on Proliferation and Osteogenic Differentiation of Human Periodontal Ligament Stem Cells In Vitro and In Vivo

1School of Life Sciences, Lanzhou University, Lanzhou, Gansu, China
2Department of Oral Implantology, School/Hospital of Stomatology, Lanzhou University, No. 199 Donggang West Road, Chengguan, Lanzhou, Gansu, China
3School/Hospital of Stomatology, Lanzhou University, No. 199 Donggang West Road, Chengguan, Lanzhou, Gansu, China
4Shanghai Institute for Advanced Immunochemical Studies (SIAIS), ShanghaiTech University, No. 99 Haike Road, Pudong, Shanghai 201210, China

Received 26 March 2015; Accepted 26 April 2015

Academic Editor: Jia Xie

Copyright © 2015 Lihua Yin et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

This study is to explore the osteogenesis potential of the human periodontal ligament stem cells (hPDLSCs) induced by naringin in vitro and in vitro. The results confirmed that 1 μM naringin performs the best effect and a collection of bone-related genes (RUNX2, COL1A2, OPN, and OCN) had significantly higher expression levels compared to the control group. Furthermore, a typical trabecular structure was observed in vivo, surrounded by a large amount of osteoblasts. These results demonstrated that naringin, at a concentration of 1 μM, can efficiently promote the proliferation and differentiation of hPDLSCs both in vitro and in vivo.