Effects of Naringin on Proliferation and Osteogenic Differentiation of Human Periodontal Ligament Stem Cells In Vitro and In Vivo

<div>RT-PCR for the determination of osteoblastic marker expression was performed on day 14 after induction. Data were presented as the mean ± SD (<svg height="8.54217pt" id="M17" style="vertical-align:-0.2063894pt" version="1.1" viewbox="-0.0498162 -8.33578 28.4588 8.54217" width="28.4588pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M504 89L488 119C453 85 428 69 416 69C408 69 405 75 412 102L462 304C492 438 460 451 436 451S388 441 356 423C311 397 229 336 170 256H168L189 340C208 418 200 451 177 451C144 451 82 413 24 352L40 322C65 345 98 369 108 369C114 369 119 363 112 335L28 -3L36 -12C54 -3 83 4 112 10C125 73 138 122 153 174C205 258 328 382 376 382C395 382 399 369 384 305L330 93C312 25 323 -12 351 -12C378 -12 439 21 504 89Z" id="g50-111"></path><glyph.data ascent="3443" descent="-2856" horiz-adv-x="512" vert-adv-y="512"></glyph.data></g><g transform="matrix(.013,0,0,-0.013,10.332,0)"><path d="M556 331V384H55V331H556ZM556 140V193H55V140H556Z" id="g54-34"></path><glyph.data ascent="3443" descent="-2856" 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vert-adv-y="487"></glyph.data></g></svg>.<i> RUNX2</i>, collagen I, OPN, and OCN expression were significantly determined in the treatment groups and were positively correlated with the naringin concentration. Among them, 1 <i>μ</i>M naringin showed the most positive effect.</div>

Stem Cells International

fig8

Figure 8

Figure 8: Effects of Naringin on Proliferation and Osteogenic Differentiation of Human Periodontal Ligament Stem Cells In Vitro and In Vivo 