Dynamic Network-Based Relevance Score Reveals Essential Proteins and Functional Modules in Directed Differentiation

Figure 3

Interaction activity variations of the ten proteins with the highest relevance scores in the IDNs at two differentiation stage transitions. (a) Interaction activity variations of the ten proteins highest in relevance score from LSB to LSB/S/F8. (b) Interaction activity variations of the ten proteins highest in relevance score from LSB/S/F8 to LSB/S/F8/CHIR. Node and edge colors and edge line styles have the same interpretation as in Figure 2. A yellow node represents a protein with a relatively high relevance score (Table 1).

(a) LSB → LSB/S/F8

(b) LSB/S/F8 → LSB/S/F8/CHIR