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Stem Cells International
Volume 2015 (2015), Article ID 954120, 10 pages
http://dx.doi.org/10.1155/2015/954120
Research Article

Study on the Dynamic Biological Characteristics of Sca-1+ Hematopoietic Stem and Progenitor Cell Senescence

1Laboratory of Stem Cells and Tissue Engineering, Department of Histology and Embryology, Chongqing Medical University, Chongqing 400016, China
2Chongqing Medical University, Chongqing 400016, China

Received 7 March 2015; Revised 19 April 2015; Accepted 5 May 2015

Academic Editor: Jia Xie

Copyright © 2015 Shan Geng et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. S. J. Morrison, A. M. Wandycz, K. Akashi, A. Globerson, and I. L. Weissman, “The aging of hematopoietic stem cells,” Nature Medicine, vol. 2, no. 9, pp. 1011–1016, 1996. View at Publisher · View at Google Scholar · View at Scopus
  2. K. Sudo, H. Ema, Y. Morita, and H. Nakauchi, “Age-associated characteristics of murine hematopoietic stem cells,” Journal of Experimental Medicine, vol. 192, no. 9, pp. 1273–1280, 2000. View at Publisher · View at Google Scholar · View at Scopus
  3. D. J. Rossi, D. Bryder, J. M. Zahn et al., “Cell intrinsic alterations underlie hematopoietic stem cell aging,” Proceedings of the National Academy of Sciences of the United States of America, vol. 102, no. 26, pp. 9194–9199, 2005. View at Publisher · View at Google Scholar · View at Scopus
  4. S. M. Chambers, C. A. Shaw, C. Gatza, C. J. Fisk, L. A. Donehower, and M. A. Goodell, “Aging hematopoietic stem cells decline in function and exhibit epigenetic dysregulation,” PLoS Biology, vol. 5, article e201, 2007. View at Google Scholar
  5. Y. Zhou, B. Yang, X. Yao, and Y. Wang, “Establishment of an aging model of Sca-1+ hematopoietic stem cell and studies on its relative biological mechanisms,” In Vitro Cellular and Developmental Biology—Animal, vol. 47, no. 2, pp. 149–156, 2011. View at Publisher · View at Google Scholar · View at Scopus
  6. E. Lagasse, H. Connors, M. Al-Dhalimy et al., “Purified hematopoietic stem cells can differentiate into hepatocytes in vivo,” Nature Medicine, vol. 6, no. 11, pp. 1229–1234, 2000. View at Publisher · View at Google Scholar · View at Scopus
  7. I. Bellantuono, “Haemopoietic stem cells,” International Journal of Biochemistry and Cell Biology, vol. 36, no. 4, pp. 607–620, 2004. View at Publisher · View at Google Scholar · View at Scopus
  8. C. Holmes and W. L. Stanford, “Concise review: stem cell antigen-1: Expression, function, and enigma,” Stem Cells, vol. 25, no. 6, pp. 1339–1347, 2007. View at Publisher · View at Google Scholar · View at Scopus
  9. A. C. Berardi, A. Wang, J. D. Levine, P. Lopez, and D. T. Scadden, “Functional isolation and characterization of human hematopoietic stem cells,” Science, vol. 267, no. 5195, pp. 104–108, 1995. View at Publisher · View at Google Scholar · View at Scopus
  10. G. J. Spangrude, S. Heimfeld, and I. L. Weissman, “Purification and characterization of mouse hematopoietic stem cells,” Science, vol. 241, no. 4861, pp. 58–62, 1988. View at Publisher · View at Google Scholar · View at Scopus
  11. A. J. Wagers, “The stem cell niche in regenerative medicine,” Cell Stem Cell, vol. 10, no. 4, pp. 362–369, 2012. View at Publisher · View at Google Scholar · View at Scopus
  12. X. Y. Fang, Medical Laboratory Zoology, People's Medical Publishing House, 1st edition, 1995.
  13. H. R. Warner, “Superoxide dismutase, aging and degenerative disease,” Free Radical Biology and Medicine, vol. 17, no. 3, pp. 249–258, 1994. View at Publisher · View at Google Scholar · View at Scopus
  14. Y. Lu, K.-H. Zhao, L. Li, R. Wang, and L. Zhang, “Lipid peroxidation and antioxidation in lens of aging rats,” Recent Advances in Ophthalmology, vol. 28, no. 4, pp. 241–244, 2008. View at Google Scholar
  15. W. Wagner, S. Bork, P. Horn et al., “Aging and replicative senescence have related effects on human stem and progenitor cells,” PLoS ONE, vol. 4, no. 6, Article ID e5846, 2009. View at Publisher · View at Google Scholar · View at Scopus