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Stem Cells International
Volume 2015 (2015), Article ID 972313, 11 pages
Review Article

Periodontal Ligament Stem Cells: Current Status, Concerns, and Future Prospects

Wenjun Zhu1,2 and Min Liang1,2

1Department of Periodontology, Guanghua School of Stomatology, Hospital of Stomatology, Sun Yat-sen University, 56 Ling Yuan Road West, Guangzhou, Guangdong 510055, China
2Guangdong Provincial Key Laboratory of Stomatology, China

Received 15 December 2014; Revised 3 March 2015; Accepted 3 March 2015

Academic Editor: Hung-Fat Tse

Copyright © 2015 Wenjun Zhu and Min Liang. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Periodontal ligament stem cells (PDLSCs), which reside in the perivascular space of the periodontium, possess characteristics of mesenchymal stem cells and are a promising tool for periodontal regeneration. Recently, great progress has been made in PDLSC transplantation. Investigators are attempting to maximize the proliferation and differentiation potential of PDLSCs by modifying culture conditions and applying growth factors. Nevertheless, problems remain. First, incomparability among different studies must be minimized by establishing standard guidelines for culture and identification of PDLSCs. Notably, attention should be paid to the biological safety of PDLSC transplantation. The present review updates the latest findings regarding PDLSCs and discusses standard criteria for culture and identification of PDLSCs. Finally, the review calls for careful consideration of PDLSC transplantation safety.