Low Reactive Level Laser Therapy for Mesenchymal Stromal Cells Therapies

Table 1

The effect of LLLT on the MSCs proliferation and differentiation (literatures published in recent 3 years).

Authors	Brief description	Reference
Park et al.	LLLT enhanced angiogenic effect of adipose-derived stromal cells (ASCs) spheroid in hind limb ischemia mice. LLLT is an effective biostimulator of spheroid ASCs in tissue regeneration that enhanced the survival of ASCs and stimulated the secretion of growth factors in the ischemic hind limb.	[126]
Farfara et al.	MSCs were stimulated by LLLT in order to affect neurological behavior and beta-amyloid burden in progressive stages of Alzheimer's disease mouse model.	[127]
Yang et al.	LLLT was applied as an adjunct therapy for MSCs transplantation on the functional recovery of crushed sciatic nerve in rats.	[128]
Wu et al.	LLLT increased the intracellular level of cAMP, which acts to downregulate NF-B transcriptional activity.	[129]
Nagata et al.	The combination of bone marrow aspirate/LLLT yielded significantly greater bone formation in surgically created critical-size defects in rat calvaria.	[130]
Manuguerra-Gagné et al.	A laser-induced model of open angle glaucoma (OAG) was used to evaluate the potential of bone marrow cell populations and the mechanisms involved in tissue repair. Laser-induced tissue remodeling as a method of targeting effector cells into damaged tissues was also evaluated.	[131]
Lipovsky et al.	The ability of broadband visible light illumination to promote proliferation of MSCs was evaluated.	[132]
Giannelli et al.	The effects of LLLT on mouse MSCs proliferation were investigated underlying cellular and molecular mechanisms, focusing the attention on the effects of laser irradiation on Notch-1 signal activation and membrane ion channel modulation.	[133]
Choi et al.	Adipose-derived mesenchymal stem cells- (ASCs-) seeded acellular dermal matrix was used with LLLT to repair bone defect.	[134]
Alexandrov et al.	Terahertz (THz) laser irradiation of MSCs can cause specific catalytic changes in cellular function that are closely related to the gene expression and differentiation state.	[135–137]
Wu et al.	The change in mRNA expression in rat MSCs after LLLT and the associated molecular mechanisms were investigated.	[138]
Wu et al.	LLLT induced IGF1 expression to promote both the proliferation and osteogenic differentiation of MSCs, whereas it may induce BMP2 expression primarily to enhance osteogenic differentiation.	[139]
Wang et al.	MicroRNA-193 proproliferation effects for bone MSCs were revealed after LLLT through inhibitor of growth family, member 5.	[140]
Soleimani et al.	The influence of LLLT at different energy densities on MSCs differentiation into neuron and osteoblast was examined.	[141]
Saygun et al.	LLLT increased the proliferation of osteoblast cells and stimulated the release of bFGF, IGF-1, and IGFBP3 from these cells.	[142]