The Therapeutic Targets of miRNA in Hepatic Cancer Stem Cells

Figure 1

Key signaling pathways that regulate the function of hepatic cancer stem cells. The cartoon recapitulates the principle signaling pathways that regulate the function of hepatic CSCs such as Wnt/β-catenin, Hedgehog, and Notch. Epithelial cell adhesion molecule (EpCAM) is a Wnt/β-catenin signaling target gene. The activation of Wnt/β-catenin signaling regulates EpCAM expression in HCSCs. In CD133⁺ HCC cells, Wnt/β-catenin, Notch1, and smoothened (SMO)/Hedgehog signaling pathways are associated with proliferation, self-renewal, and differentiation of HCSCs.