The Therapeutic Targets of miRNA in Hepatic Cancer Stem Cells

Table 2

The regulatory functions of miRNAs in HCSCs biology.

miRNA	Oncogene (OG); oncosuppressor (OS)	Molecular target/pathways	Effects	Ref.
miR-10b	OG	HOX transcript antisense RNA (HOTAIR)	E-cadherin degradation; EMT	[34]
miR-21	OG	PTEN, RECK, and PDCD4	Migration/invasion	[35]
miR-122	OS	PDK4, LDHA, and; CD133	Glycolysis inhibition; increased CD133^+	[36, 37]
miR-125b	OS	SMAD2, SMAD4	EMT	[38]
miR-142-3p	OG	CD-133	HCSC features	[39]
miR-145	OS	OCT4	Tumorigenesis enhancing	[40]
miR-148a	OS	TGF-β/SMAD2	HCSC-features	[41]
miR-148b	OS	NRP1	HCSC-features	[42]
miR-150	OG/OS	3′UTR of mRNA c-myb	Cyclin D1/Bcl-2	[43, 44]
miR-152	OS	KIT	HCSC-features	[45]
miR-155	OG	TGF-β1/TP53INP1	EMT; Decreased EpCAM^+	[43, 46]
miR-181	OG	let-7; CDX2, GATA6, and NLK	Doxorubicin sorafenib resistance	[47, 48]
miR-200a	OG/OS	VASH2 in ZEB1/2 signaling; Wnt/β-catenin	Transition LCSC/HCSC; N-cadherin, ZEB2, and vimentin	[49, 50]
miR-205	OS	PLCβ1	HCSC-features	[51]
miR-214	OS	EZH2 in Wnt/β-catenin signaling	EpCAM^+	[52]
miR-216a	OG	PTEN and SMAD7; TGF-β1/PI3K/AKT	EMT; Sorafenib resistance	[53]
miR-217	OG	PTEN and SMAD7; TGF-β1/PI3K/AKT	EMT; Sorafenib resistance	[53]
miR-223	OG	—	HCSC-features	[43, 54]
miR-491	OS	GIT-1/NF-κB	HCSC-features	[55]
miR-612	OS	AKT2	EMT	[56]