Muscle Satellite Cells: Exploring the Basic Biology to Rule Them

Figure 3

Quiescence and activation control. Notch signaling is one of the main pathways controlling quiescence. Foxo transcription factors regulate Notch receptors expression facilitating this pathway’s activity. MicroRNAs target cell cycle genes and myogenic regulators. Upon injury, signaling molecules are released and pathways related to cell cycle progression are turned on. After some rounds of division, some cells return to quiescence whereas the others exit cell cycle and proceed into the myogenic program, differentiate, and repair the damage.