Expression of CD24 in Human Bone Marrow-Derived Mesenchymal Stromal Cells Is Regulated by TGFβ3 and Induces a Myofibroblast-Like Genotype

Table 1

IPA upstream regulator analysis. Molecules resulting in similar changes in the pattern of gene expression as the overexpression of CD24 or the knockdown of CD24 are designated with high activational -score values. Listed are those molecules with a -score higher than 2 while exhibiting opposing algebraic signs in the CD24 Up and CD24 Down Groups.

Upstream regulators	Activational; -score		Alias	Function of encoded protein
	CD24 Up	CD24 Down
SMAD7	−3,435	2,136	MAD (Mothers Against Decapentaplegic, Drosophila) Homolog 7	Antagonist of signaling by TGFβ1 receptor superfamily members [23]
NF-B1	−2,995	2,222	NF-B1	Transcription factor that plays a key role in regulating many intracellular signaling events and the immune response to infection [24]
IFNAR1	−2,566	2,927	Interferon (alpha, beta, and omega) receptor 1	Forms one of the two chains of a receptor for interferons alpha and beta [25]
Y 27632	−2,558	2,198		Inhibitor of p160 rho-associated protein kinase (ROCK) [26]
CR1L	−2,412	2,728	Complement component (3b/4b) receptor 1-like	May function as membrane-bound inhibitor of complement activation [27]
NPR1	−2,345	2,426	Natriuretic peptide receptor A/guanylate cyclase A	Receptor for certain natriuretic peptides [28]
SRF	2,404	−2,257	Serum response factor	Transcription factor that binds to the serum response element [29]