A Genomic Study of DNA Alteration Events Caused by Ionizing Radiation in Human Embryonic Stem Cells via Next-Generation Sequencing

Table 3

Rare variants identified in the four human embryonic stem cell lines after exposure to 1 Gy of ionizing radiation.

Cell line	Position	Gene	Reference	Variant	314 chip		318 chip		318 chip-2
					Frequency	Coverage	Frequency	Coverage	Frequency	Coverage
H1	chr4:55593481	KIT	A	G	2.7%	673	3.1%	4,325	3.1%	4,870
H7	chr11:108225561	ATM	T	C	1.25%	320	—	2,486	—	1,407
H9	chr5:112175620	APC	T	G	7.4%	269	8.2%	1,798	—	3,089
	chr7:55249049	EGFR	A	G	5.5%	109	—	994	—	1,416
	chr7:128846391	SMO	C	T	1.25%	319	—	3121	—	3,524
	chr7:128846393	SMO	T	A	2.22%	316	3.5%	3,228	—	3,526