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Stem Cells International
Volume 2016 (2016), Article ID 1384658, 9 pages
Review Article

Nanoparticles-Assisted Stem Cell Therapy for Ischemic Heart Disease

1Department of Cardiac Surgery, Zhongshan Hospital, Fudan University, Shanghai 200032, China
2Shanghai Institute of Cardiovascular Disease, Shanghai 200032, China

Received 13 July 2015; Revised 4 October 2015; Accepted 8 October 2015

Academic Editor: Franca Fagioli

Copyright © 2016 Kai Zhu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Stem cell therapy has attracted increasing attention as a promising treatment strategy for cardiac repair in ischemic heart disease. Nanoparticles (NPs), with their superior physical and chemical properties, have been widely utilized to assist stem cell therapy. With the help of NPs, stem cells can be genetically engineered for enhanced paracrine profile. To further understand the fate and behaviors of stem cells in ischemic myocardium, imaging NPs can label stem cells and be tracked in vivo under multiple modalities. Besides that, NPs can also be used to enhance stem cell retention in myocardium. These facts have raised efforts on the development of more intelligent and multifunctional NPs for cellular application. Herein, an overview of the applications of NPs-assisted stem cell therapy is given. Key issues and future prospects are also critically addressed.