Slowly Delivered Icariin/Allogeneic Bone Marrow-Derived Mesenchymal Stem Cells to Promote the Healing of Calvarial Critical-Size Bone Defects

Figure 3

Graphs depicting the fold changes of the expression of osteogenesis-related and angiogenesis-related mRNA in BMSCs under the stimulation of icariin for 3 days, 5 days, 7 days, and 14 days. (a) Runx2, (b) alkaline phosphatase (ALP), (c) osteocalcin (OCN), (d) fibroblast growth factors (FGF), and (e) vascular endothelial growth factor (VEGF). All data are presented as mean values together with the standard deviation (SD). ; indicating the statistical difference between the experimental group (with icariin) and the control group (no icariin) at the same time point.

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