GDNF Enhances Therapeutic Efficiency of Neural Stem Cells-Based Therapy in Chronic Experimental Allergic Encephalomyelitis in Rat

Figure 4

Double-immunohistochemical staining showed differentiation of transplanted NSCs or GDNF/NSCs in the corpus striatum. (a, b) BrdU⁺ cells (solid arrow), MAP2⁺ cells (dotted arrow), and MAP2⁺/BrdU⁺ cells (arrowhead) in NSCs group and GDNF/NSCs group, respectively. (c, d) BrdU⁺ positive cells (solid arrow), GalC⁺ cells (dotted arrow), and GalC⁺/BrdU⁺ cells (arrowhead) in NSCs group and GDNF/NSCs group, respectively. (e, f) BrdU⁺ cells (solid arrow), GFAP⁺ cells (dotted arrow), and GFAP⁺/BrdU⁺ cells (arrowhead) in NSCs group and GDNF/NSCs group, respectively. (g) Quantitative analysis of BrdU⁺ cells in NSCs and GDNF/NSCs groups (mean ± SD, ). with NSCs group, . (h) Quantitative analysis of the ratio of transplanted NSCs and GDNF/NSCs differentiated into each type of neural cells (mean ± SD, ). with NSCs group, . Bar = 25 μm.

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