Table of Contents Author Guidelines Submit a Manuscript
Stem Cells International
Volume 2016, Article ID 1431349, 9 pages
http://dx.doi.org/10.1155/2016/1431349
Research Article

GDNF Enhances Therapeutic Efficiency of Neural Stem Cells-Based Therapy in Chronic Experimental Allergic Encephalomyelitis in Rat

1Department of Anatomy and Neurobiology, Southwest Medical University, Zhongshan Road, Luzhou, Sichuan 646000, China
2Preclinical Medicine Research Center, Southwest Medical University, Zhongshan Road, Luzhou, Sichuan 646000, China
3Department of Anatomy and Neurobiology, Tongji University School of Medicine, Siping Road, Shanghai 200092, China

Received 30 December 2015; Revised 13 March 2016; Accepted 3 April 2016

Academic Editor: Kaylene Young

Copyright © 2016 Xiaoqing Gao et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. J. M. Fletcher, S. J. Lalor, C. M. Sweeney, N. Tubridy, and K. H. G. Mills, “T cells in multiple sclerosis and experimental autoimmune encephalomyelitis,” Clinical and Experimental Immunology, vol. 162, no. 1, pp. 1–11, 2010. View at Publisher · View at Google Scholar · View at Scopus
  2. G. C. Furtado, M. C. G. Marcondes, J.-A. Latkowski, J. Tsai, A. Wensky, and J. J. Lafaille, “Swift entry of myelin-specific T lymphocytes into the central nervous system in spontaneous autoimmune encephalomyelitis,” The Journal of Immunology, vol. 181, no. 7, pp. 4648–4655, 2008. View at Publisher · View at Google Scholar · View at Scopus
  3. J. Yang, Y. Yan, C.-G. Ma et al., “Accelerated and enhanced effect of CCR5-transduced bone marrow neural stem cells on autoimmune encephalomyelitis,” Acta Neuropathologica, vol. 124, no. 4, pp. 491–503, 2012. View at Publisher · View at Google Scholar · View at Scopus
  4. J. Yang, Y. Yan, Y. Xia et al., “Neurotrophin 3 transduction augments remyelinating and immunomodulatory capacity of neural stem cells,” Molecular Therapy, vol. 22, no. 2, pp. 440–450, 2014. View at Publisher · View at Google Scholar · View at Scopus
  5. S. Grade, L. Bernardino, and J. O. Malva, “Oligodendrogenesis from neural stem cells: perspectives for remyelinating strategies,” International Journal of Developmental Neuroscience, vol. 31, no. 7, pp. 692–700, 2013. View at Publisher · View at Google Scholar · View at Scopus
  6. F. Sher, S. Amor, W. Gerritsen et al., “Intraventricularly injected Olig2-NSCs attenuate established relapsing-remitting EAE in mice,” Cell Transplantation, vol. 21, no. 9, pp. 1883–1897, 2012. View at Publisher · View at Google Scholar · View at Scopus
  7. M. Aharonowiz, O. Einstein, N. Fainstein, H. Lassmann, B. Reubinoff, and T. Ben-Hur, “Neuroprotective effect of transplanted human embryonic stem cell-derived neural precursors in an animal model of multiple sclerosis,” PLoS ONE, vol. 3, no. 9, Article ID e3145, 2008. View at Publisher · View at Google Scholar · View at Scopus
  8. M. E. Cohen, N. Muja, N. Fainstein, J. W. M. Bulte, and T. Ben-Hur, “Conserved fate and function of ferumoxides-labeled neural precursor cells in vitro and in vivo,” Journal of Neuroscience Research, vol. 88, no. 5, pp. 936–944, 2010. View at Publisher · View at Google Scholar · View at Scopus
  9. L.-F. H. Lin, D. H. Doherty, J. D. Lile, S. Bektesh, and F. Collins, “GDNF: a glial cell line-derived neurotrophic factor for midbrain dopaminergic neurons,” Science, vol. 260, no. 5111, pp. 1130–1132, 1993. View at Publisher · View at Google Scholar · View at Scopus
  10. C. E. Henderson, H. S. Phillips, R. A. Pollock et al., “GDNF: a potent survival factor for motoneurons present in peripheral nerve and muscle,” Science, vol. 266, no. 5187, pp. 1062–1064, 1994. View at Publisher · View at Google Scholar · View at Scopus
  11. M. S. Ramer, J. V. Priestley, and S. B. McMahon, “Functional regeneration of sensory axons into the adult spinal cord,” Nature, vol. 403, no. 6767, pp. 312–316, 2000. View at Publisher · View at Google Scholar · View at Scopus
  12. A. Blesch and M. H. Tuszynski, “Cellular GDNF delivery promotes growth of motor and dorsal column sensory axons after partial and complete spinal cord transections and induces remyelination,” Journal of Comparative Neurology, vol. 467, no. 3, pp. 403–417, 2003. View at Publisher · View at Google Scholar · View at Scopus
  13. L. Zhang, Z. Ma, G. M. Smith et al., “GDNF-enhanced axonal regeneration and myelination following spinal cord injury is mediated by primary effects on neurons,” GLIA, vol. 57, no. 11, pp. 1178–1191, 2009. View at Publisher · View at Google Scholar · View at Scopus
  14. B. Chen, X.-Q. Gao, C.-X. Yang et al., “Neuroprotective effect of grafting GDNF gene-modified neural stem cells on cerebral ischemia in rats,” Brain Research, vol. 1284, pp. 1–11, 2009. View at Publisher · View at Google Scholar · View at Scopus
  15. S. Pluchino, A. Quattrini, E. Brambilla et al., “Injection of adult neurospheres induces recovery in a chronic model of multiple sclerosis,” Nature, vol. 422, no. 6933, pp. 688–694, 2003. View at Publisher · View at Google Scholar · View at Scopus
  16. S. Pluchino, L. Zanotti, B. Rossi et al., “Neurosphere-derived multipotent precursors promote neuroprotection by an immunomodulatory mechanism,” Nature, vol. 436, no. 7048, pp. 266–271, 2005. View at Publisher · View at Google Scholar · View at Scopus
  17. S. Pluchino, L. Zanotti, E. Brambilla et al., “Immune regulatory neural stem/precursor cells protect from central nervous system autoimmunity by restraining dendritic cell function,” PLoS ONE, vol. 4, no. 6, Article ID e5959, 2009. View at Publisher · View at Google Scholar · View at Scopus
  18. R. Brambilla, P. D. Morton, J. J. Ashbaugh, S. Karmally, K. L. Lambertsen, and J. R. Bethea, “Astrocytes play a key role in EAE pathophysiology by orchestrating in the CNS the inflammatory response of resident and peripheral immune cells and by suppressing remyelination,” Glia, vol. 62, no. 3, pp. 452–467, 2014. View at Publisher · View at Google Scholar · View at Scopus
  19. C. Hackett, J. Knight, and Y. Mao-Draayer, “Transplantation of Fas-deficient or wild-type neural stem/progenitor cells (NPCs) is equally efficient in treating experimental autoimmune encephalomyelitis (EAE),” American Journal of Translational Research, vol. 6, no. 2, pp. 119–128, 2014. View at Google Scholar · View at Scopus
  20. O. Einstein, N. Grigoriadis, R. Mizrachi-Kol et al., “Transplanted neural precursor cells reduce brain inflammation to attenuate chronic experimental autoimmune encephalomyelitis,” Experimental Neurology, vol. 198, no. 2, pp. 275–284, 2006. View at Publisher · View at Google Scholar · View at Scopus
  21. L. Calza, M. Fernandez, A. Giuliani, L. Aloe, and L. Giardino, “Thyroid hormone activates oligodendrocyte precursors and increases a myelin-forming protein and NGF content in the spinal cord during experimental allergic encephalomyelitis,” Proceedings of the National Academy of Sciences of the United States of America, vol. 99, no. 5, pp. 3258–3263, 2002. View at Publisher · View at Google Scholar · View at Scopus
  22. C. M. Rice, K. Kemp, A. Wilkins, and N. J. Scolding, “Cell therapy for multiple sclerosis: an evolving concept with implications for other neurodegenerative diseases,” The Lancet, vol. 382, no. 9899, pp. 1204–1213, 2013. View at Publisher · View at Google Scholar · View at Scopus
  23. S. Obayashi, H. Tabunoki, S. U. Kim, and J.-I. Satoh, “Gene expression profiling of human neural progenitor cells following the serum-induced astrocyte differentiation,” Cellular and Molecular Neurobiology, vol. 29, no. 3, pp. 423–438, 2009. View at Publisher · View at Google Scholar · View at Scopus
  24. Z. Gao, Q. Wen, Y. Xia et al., “Osthole augments therapeutic efficiency of neural stem cells-based therapy in experimental autoimmune encephalomyelitis,” Journal of Pharmacological Sciences, vol. 124, no. 1, pp. 54–65, 2014. View at Publisher · View at Google Scholar · View at Scopus
  25. M. Fernandez, A. Giuliani, S. Pirondi et al., “Thyroid hormone administration enhances remyelination in chronic demyelinating inflammatory disease,” Proceedings of the National Academy of Sciences of the United States of America, vol. 101, no. 46, pp. 16363–16368, 2004. View at Publisher · View at Google Scholar · View at Scopus
  26. F. Girolamo, G. Ferrara, M. Strippoli et al., “Cerebral cortex demyelination and oligodendrocyte precursor response to experimental autoimmune encephalomyelitis,” Neurobiology of Disease, vol. 43, no. 3, pp. 678–689, 2011. View at Publisher · View at Google Scholar · View at Scopus