Regenerative Potential of Mesenchymal Stromal Cells: Age-Related Changes

Figure 1

Adult donor syngeneic BM-MSCs accelerated wound closure kinetics. A murine excisional wound model in which wounds were treated with (a) 0.5 × 10⁶ and (b) 1 × 10⁶ BM-MSCs isolated from female young, adult, and old C57BL/6 or 5% autologous plasma in physiological saline (vehicle). Representative photographs of wounds in C57BL/6 before treatment or 4, 8, and 12 days afterwards. Wound size measurement at different times. Data are mean ± SEM (vehicle ; 0.5 × 10⁶ BM-MSCs isolated from young (), adult (), and old () and 1 × 10⁶ BM-MSCs isolated from young (), adult (), and old ()).   : young, adult, and old versus vehicle.   : adult versus young and old.

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