TGF-β1 Induces the Dual Regulation of Hepatic Progenitor Cells with Both Anti- and Proliver Fibrosis

Figure 6

SERPINE1 is required for HPC-mediated amelioration of liver injury induced by an injection of CCl₄. The layout of the genes included in the EMT Pathway Finder PCR Array (a). The heat map of the variations in the expression levels of 84 genes between control HPCs and HPCs treated with TGF-β1 for 12 h or 48 h is shown as a fold increase or decrease (b). Validation of SERPINE1 expression by real-time PCR analysis (c). All data are expressed as the mean ± SD from three independent experiments.

(a)

(b)

(c)