TGF-β1 Induces the Dual Regulation of Hepatic Progenitor Cells with Both Anti- and Proliver Fibrosis

Figure 7

Influence of the SERPINE1 inhibitor on HSC activation after HSCs were cocultured with HPCs pretreated with TGF-β1 for 12 h. After incubation with various concentrations of the SERPINE1 inhibitor PAI-039 (0–10 μM) for 48 h, SERPINE1 expression was inhibited significantly as shown by immunofluorescence (a) and real-time PCR (b) analyses. Suppression of SERPINE1 expression prevented the response of HSCs to HPCs. Data are expressed as the mean ± SD from three independent experiments.

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